We need inclusive, multi-institutional collaboration that centers the diversity of knowledge creators and fields of inquiry as a strength. With much of the world’s knowledge currently inaccessible due to paywalls and structural obstacles, existing knowledge ecosystems are broken and serve financial incentives rather than the public good. Through this program, we create new, healthier life cycles for discovering and communicating knowledge. We explore the strengths and weaknesses of existing systems, their bottlenecks and biases, and build models that move us towards growing, resilient knowledge ecosystems. To start, we ask, who is the future for and what tools do we need to build it? We convene organizations with a broad range of expertise to conduct that research, host conversations with diverse and interdisciplinary communities, build open tools, and create playbooks so others can implement, and further develop themselves, healthier knowledge ecosystems.